国际自闭症诊疗团队负责人李笑虹教授公益讲座（6月3日9：30太原晋阳学堂）！

自闭症谱系障碍的早期检测诊断和治疗进展 

李笑虹 (Xiaohong Li)

美籍华人

●美国纽约州立基础研究院, 终身研究员, 细胞神经生物研究室主任

●纽约基因通路诊断公司(Gene-Path Diagnositcs) 顾问

●上海交大医学院, 博士导师, 客座教授

●自闭症国际诊疗团队负责人（团队成员：哈佛大学医学博士Ted Brown 教授、澳大利亚皇家医生组委会儿童健康主委Jaqueline Small 教授，波多黎各大学医学院慱士Saidi Clements 教授， 新英格兰大学行为分析慱士Dr. April Kisamore，英国剑桥大学计算机生物化学愽士Ian Alberts 教授）

●获奖：

1991-1992: 香港体育学院访问学者基金  

1992-1995: 英国剑桥海外留学生基金

1993-1994: 英国剑桥New Hall 学院研究基金

1994-1995: 英国研究生研究基金

1999-2001: 美国肾脏基金会 Fellowship

2001-2004: 国家科研服务奖 (National Research Service Award), 美国NIH

2002-2007: 二百万美元研究基金 (和Wilson 教授一起获得), 美国NIH

2009-2011:美国密西根研究基金会基金

2010-2012:美国Richmond 研究基金会基金

2011-2012:美国Northfield研究基金会基金  

2011-2012:美国Simons研究基金会基金

2010:上海交通大学医学院推荐，入选“上海高校特聘教授”（东方学者“讲座教授”）

2011:上海交通大学医学院推荐，入选首批“上海千人计划”特聘专家-短期

2012:入选“湖南省百人计划”特聘专家

2015:获中国自然科学基金会“国际合作基金”

●主要成果：近十几年代表性SCI收录论文 40篇,  总影响因子超过200. 为其中25 篇的通讯作者

1. Patricia D. Wilson, Olivier Devuyst, Xiaohong Li, Laura Gatti, Doris Falkenstein, Shawn Robinson, Douglas Fambrough and Christopher R. Burrow.  Apical plasma membrane mispolarization of NaK-ATPase in polycystic kidney disease epithelia is associated with aberrant expression of the b2 isoform.  Am. J. Pathology, 156, 253-267, 2000.  

2. Geoffrey E. Woodard, Xiaohong Li, Juan A. Rosado. Receptor subtypes for vasonatrin peptide in renal glomeruli and arteries. Regulatory Peptides 129:183-189, 2005  

3. Xiaohong Li, Dehorah P. Hyink, Katalin Polgar, G. Luca Gusella, Patricia D. Wilson, and Christopher R. Burrow. Protein Kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney. J Am Soc Nephrol 16:3543-3552, 2005.  

4. Samantha J. Wilson, Kurt Amsler, Deborah P Hyink, Xiaohong Li, Weining Lu, Jing Zhou, Christopher R. Burrow, Patricia D. Wilson. Inhibition of HER-2 (new/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia.  Biochim Biophys Acta --Molecular Basis of Disease 1762(7), 647-55. 2006  

5. Xiaohong Li*, Geoffrey E. Woodard, Juan A. Rosado. Renal atrail natriuretic peptide receptors binding properties and function are resistant to DOCA-salt-induced hypertension in rats. Regulatory Peptides 127:114-120, 2006   

6. Lorenzo Battini, Elena Fedorova, Salvador Macip, Xiaohong Li, Patricia D. Wilson and G. Luca Gusella. Stable Knockdown of Polycystin-1 Confers Integrin-a2b1–Mediated Anoikis Resistance. J Am Soc Nephrol 17: 3049-3058, 2006  

7. Xiaohong Li*, Christopher R. Burrow, Katalin Polgar, Deborah Hyink and Patricia D, Wilson. PRKX can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.  Biochim Biophys Acta-- Molecular Basis of Disease, 1782(1): 1-9, 2008  

8. D Chen, Y Wei, Xiaohong Li, S Epstein, JM Wolosin, P Asbell. sPLA2-IIa is an inflammatory mediator when the ocular surface is compromised. Exp Eye Res. 88(5): 880-888, 2009  

9. ML Massingale, Xiaohong Li, M Vallabhajosyula, D Chen, Y Wei, PA Asbell.  Analysis of Inflammatory Cytokines in the Tears of Dry Eye Patients. Cornea, 28(9):1023-1027, 2009  

10. Xiaohong Li*, Deborah P. Hyink, Brian Radbill,  Patricia  D. Wilson. siRNA analysis of the physiological effects of PRKX on renal epithelial cell migration and  kidney development.  Kidney International. 76(1) 54-62, 2009  

11. Xiaohong Li*, Abha Chauhan , Ashfaq M. Sheikh , Sangita Patil , Ved Chauhan , Xiu-Min Li , Lina Ji, Ted Brown , Mazhar Malik.   Elevated immune response in the brain of autistic patients. J. of Neuroimmunol, 207: 111-116, 2009   

12. Ashfaq M. Sheikh, Xiaohong Li*, Guang Wen, Zujaja Tauqeer, William T. Brown, Mazhar Malik. Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects. Neuroscience. 165: 363-370, 2010 (First and second author equal contribution)  

13. Mazhar Malik, Ashfaq M. Sheikh, Guang Wen, Warren Spivack, William T. Brown and Xiaohong Li*. Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects. Immunobiology, 216(1-2):80-85, 2010.  

14. Ashfaq M. Sheikh, Mazhar Malik, Guang Wen, Abha Chauhan , Ved Chauhan, Chengxin Gong, Fei Liu, Ted Brown, Xiaohong Li*.  BDNF/Akt/Bcl2 signaling pathway is compromised in the brain of autistic subject. J. Neurosci. Res. 88(12): 2641-7, 2010.  

15. Angela Wandinger-Ness, Catherine Case, Needham Qamar,  Xiaohong Li,  Deborah Hyink  Tamara Roitbak, Elsa Romero, Ward Christopher, Patricia Wilson, Richard Sandford. Receptor protein tyrosine phosphatases are novel components of a polycystin complex. Biochim Biophys Acta --Molecular Basis of Disease.  1812(10):1225-38, 2011

16. Xiaohong Li*, Carlo Iomini, Deborah Hyink, Patricia Wilson. PRKX Critically Regulates Endothelial Cell Proliferation, Migration, and Tube-like Structure Formation. Developmental Biology,  356(2)475-85, 2011

17. Mazhar Malik, Michael Fenko, Ashfaq M Sheikh, Guang Wen, Xiaohong Li*. A Novel Approach for Characterization of Cathepsin D Protease and Its Effect on Tau and β-Amyloid Proteins. Neurochem Res. 36(5):754-60, 2011

18. Xiaohong Li*. Phosphorylation, protein kinases and ADPKD. Invited review. BBA--Molecular Basis of Disease.  12(10):1219-24, 2011

19. Hongen Wei, Hua Zou, Ashfaq Sheikh, Mazhar Malik, Carl Dobkin, Ted Brown, Xiaohong Li*. L-6 is increased in the cerebellum of the autistic brain and alters neural cell adhesion, migration and synapse formation. J Neuroinflammation. 2011 May 19;8(1):52. [Epub ahead of print]

20. Xiaohong Li*, Hua Zou, Ted Brown. Gene expression in autism. Invited review. Brain Research Bulletin. 2011.  

21. Mazhar Malik, Zujaja Tauqeer, Ashfaq Sheikh, Guang Wen, Amenah Nagori, Kun Yang, Ted Brown, Xiaohong Li*. NF-kB signaling in the Brain of Autistic Subjects. Mediators of Inflammation. 785265. Epub 2011 Oct 20.

22. Hongen Wei, Mazhar Malik, Ashfaq M. Sheikh, George Merz, William T. Brown, Xiaohong Li*. Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects. Am J Pathology. 179(1):66-74, 2011

23. Hongen Wei, Carl Dobkin, Ashfaq M. Sheikh, Mazhar Malik, W. Ted Brown, Xiaohong Li*. The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome.  PLoS One. 2012;7(5):e36981. Epub 2012 May 15.

24. Kun Yang, Ashfaq M. Sheikh, Mazhar Malik, Guang Wen, Hongen Wei, W. Ted Brown,  Xiaohong Li*. Up-regulation of Ras/Raf/ERK1/2 signaling in the autistic brain impairs neural cell migration, neurogenesis, synapse formation and dendritic spine development. Brain Structure and Function, 2013 May;218(3):669-82

25. Hongen Wei,  Kathryn K. Chadman ,  Daniel P. McCloskey , Ashfaq M. Sheikh , Mazhar Malik, W. Ted Brown ,  Xiaohong Li*. Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors. BBA--Molecular Basis of Disease.  2012 Jun;1822(6):831-42. Epub 2012 Feb 2  

26. Hongen Wei, Susumu Mori, Kegang Hua, Xiaohong Li#. Alteration of Brain volume in IL-6 overexpressiong mice related to autism. International Journal of Developental Neurosceince. 30(7), 554-559, 2012.

27.  Hongen Wei, Alberts I, Xiaohong Li*. Brain IL-6 and autism.   Neuroscience,  2013 Nov 12;252:320-5. doi: 10.1016/j.neuroscience.2013.08.025. Epub 2013 Aug 28

28. Jianling Chen, Albets I, Xiaohong Li*, Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders. Int J Dev Neurosci. 2014 Mar 21;35C:35-41. doi: 10.1016/j.ijdevneu.2014.03.006. [Epub ahead of print]

29. Peipei Chen, Albets I, Xiaohong Li*, The role of ERK1/2 in the regulation of proliferation and differentiation of astrocytes in developing brain. Int J Dev Neurosci. 2013 Dec;31(8):783-9. doi: 10.1016/j.ijdevneu.2013.09.008. Epub 2013 Oct 7.

30. Hongen Wei, Alberts I, Xiaohong Li*. The apoptotic perspective of autism.  Int J Dev Neurosci. 2014 Aug;36:13-8

31. Jianling Chen, Shunying Yu, Yingmei Fu, Xiaohong Li*: Synaptic proteins and receptors defects in autism spectrum disorders. Front Cell Neurosci, 2014 Sep 11;8:276. doi: 10.3389/fncel.2014.00276. eCollection 2014.

32. Sizhou Huang, Ian Alberts, Qian Li, Xiaohong Li*, PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development. J Cell Biochem.2015 Aug 7. doi: 10.1002/jcb.25304. [Epub ahead of print]

33. Runmei Zou, Shuo Wang, Liping Zhu,Lijia Wu, Ping Lin, Fang Li, Zhenwu Xie,

Xiaohong Li & Cheng Wang. Calgary score and modified Calgary score in the differential diagnosis between neurally mediated syncope and epilepsy in children. Neurological Sciences.  DOI 10.1007/s10072-016-2740-5

34. Chen J, Wu W, Fu Y, Yu S, Cui D, Zhao M, Du Y, Li J, Li X. Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism. Exp Ther Med 2016 Sep;12(3):1293-1298

●学术协会:

美国细胞生物协会会员

美国自闭症协会会员

●担任以下 国际杂志评委或编委:

Pediatrics  

Neurotoxicology and Teratology

Frontiers in Aging Neuroscience 

Journal of Neuroscience Research

Neurotoxicity Research

Acta Biochimica et Biophysica Sinica

Neurotoxicology and Teratology

International Journal of Nutrition, Pharmacology and Neurological Diseases 

Brain, Behavior and Immunity

Current Gene Therapy

●担任以下研究基金国际评委：

The Research Council of the Sultanate of Oman研究基金会 (国际评委).

● 近几年 应邀学术讲座, 主持国际学术会议, 担任国际期刊客座主编等：

多次应邀国际大会报告

国际转化医学及个性医疗大会, 特邀担任大会执行副主席及大会报告

应邀担任湖南省儿童医院的客座教授并主持合作研究

应邀参与主持自闭症国际合作研究项目

应邀参与美国国内大型自闭症药物合作研究课题

应邀BBA, Brain Research Bulletin, Mediators of Inflammation等国际重要医学研究刊物撰写本研究领域的综述 (review)

应邀伦敦大学参编在自闭症研究领域里最权威一书（自闭症全面指导The Comprehensive Guide to Autism）

   随着近些年我国自闭症谱系障碍的发生率不断提高的（根据《中国自闭症教育康复行业发展状况报告》，我国至少有超过1000万的自闭症人群，并以每年近20万的速度增长。）同时，国内在自闭症领域又相对薄弱，社会大众普遍对自闭症群体比较陌生，缺乏正确的认识，常常因为不了解而错过黄金的干预时期，干预方法也相对落后。近些年，李笑虹教授不停地在外学习探索，致力于将国际上最科学的治疗方法带回国内。  本次，我们有幸请到了李笑虹教授，为大家带来精彩的自闭症谱系障碍的早期检测诊断和治疗进展的讲座，欢迎每一位关注星星的孩子的家长、老师、医疗工作者及相关从事特殊教育行业的工作者踊跃参加！参会地址：太原晋阳学堂六层会议室！

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